Neck Humbucker
Can I use a Humbucker and two single coils on a guitar?
I want to make my own guitar and I want a bluesy rock sound. I've been doing research and need help . I want to put a Gibson 500T on the bridge but then what do I use for the neck and middle? Also I want them to be affordable and effective. Do I use one single coil or two. If I buy a set of three can I only use two that I want??. .. any help would be nice 
I had a Yamaha Pacifica as my first guitar(GREAT beginner guitar, by the way) with a 5 tone selector between two single coils and a humbucker.
Here's the thing, Blues depends on your phrasing, the notes you're playing, your feel, your pickups, and your amp.(well, for the ideal package. good blues can come from feeling alone but for the sake of this I'm covering everything)
Strats are known for their clean and bluesy tones, and they use 3 single coil pickups. However, if you don't blast the volume and reverb, you can get a great bluesy sound out of a humbucker. Jimmy Page is a nice example of this, since he used a Les Paul on stage.(but a Tele in the studio, I believe)
It's all up to you. Humbuckers go just fine with single coils in my opinion.
By the way, I don't know what exactly your definition of affordable is, but I'll give you my answer.
If you want awesome pickups that can cover blues and rock, I'd go with a Seymour Duncan humbucker, one Seymour Duncan single coil, and then for the other one, a Dimarzio. Put the Dimarzio in the middle, the single coil Seymour Duncan at the neck, and then the SD humbucker at the bridge.
Those pickups set up like that would be ideal for me, and would cover pretty much anything.
Good luck with your choices and playing.